264115

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 242679..243201 Replicon plasmid pB431_1
Accession NZ_CP110662
Organism Klebsiella pneumoniae strain B431

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag OOS97_RS26355 Protein ID WP_004181778.1
Coordinates 242917..243201 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag OOS97_RS26350 Protein ID WP_004181777.1
Coordinates 242679..242927 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOS97_RS26330 (OOS97_26330) 237888..238709 - 822 WP_004181772.1 hypothetical protein -
OOS97_RS26335 (OOS97_26335) 238771..239124 - 354 WP_004181774.1 hypothetical protein -
OOS97_RS26340 (OOS97_26340) 239269..240255 - 987 WP_025368599.1 hypothetical protein -
OOS97_RS26345 (OOS97_26345) 240589..242388 - 1800 WP_004181776.1 ATP-dependent helicase -
OOS97_RS26350 (OOS97_26350) 242679..242927 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OOS97_RS26355 (OOS97_26355) 242917..243201 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OOS97_RS26360 (OOS97_26360) 243218..243319 - 102 Protein_265 IS200/IS605 family transposase -
OOS97_RS26365 (OOS97_26365) 243355..244581 + 1227 WP_040209639.1 RNA-guided endonuclease TnpB family protein -
OOS97_RS26370 (OOS97_26370) 244852..245076 - 225 Protein_267 transposase -
OOS97_RS26375 (OOS97_26375) 245155..245583 - 429 WP_077257669.1 IS200/IS605 family transposase -
OOS97_RS26380 (OOS97_26380) 245619..246806 + 1188 WP_040209642.1 RNA-guided endonuclease TnpB family protein -
OOS97_RS26385 (OOS97_26385) 246851..247222 - 372 WP_040209644.1 hypothetical protein -
OOS97_RS26390 (OOS97_26390) 247219..247563 - 345 WP_223811496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / aph(3')-Ia / aac(3)-IId / sul1 / qacE / aadA16 / dfrA27 / ARR-3 pla 1..315621 315621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T264115 WP_004181778.1 NZ_CP110662:242917-243201 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT264115 WP_004181777.1 NZ_CP110662:242679-242927 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References