Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 35568..36478 | Replicon | plasmid pB431_1 |
| Accession | NZ_CP110662 | ||
| Organism | Klebsiella pneumoniae strain B431 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | OOS97_RS25285 | Protein ID | WP_004026354.1 |
| Coordinates | 36008..36478 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | OOS97_RS25280 | Protein ID | WP_004026357.1 |
| Coordinates | 35568..36011 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OOS97_RS25265 (OOS97_25265) | 31195..32226 | + | 1032 | WP_004026364.1 | hypothetical protein | - |
| OOS97_RS25270 (OOS97_25270) | 33774..34196 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| OOS97_RS25275 (OOS97_25275) | 34196..35467 | + | 1272 | WP_004026359.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| OOS97_RS25280 (OOS97_25280) | 35568..36011 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| OOS97_RS25285 (OOS97_25285) | 36008..36478 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| OOS97_RS25290 (OOS97_25290) | 36933..37121 | - | 189 | WP_024198076.1 | hypothetical protein | - |
| OOS97_RS25295 (OOS97_25295) | 37733..37993 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| OOS97_RS25300 (OOS97_25300) | 38685..39764 | - | 1080 | WP_085844512.1 | IS481-like element ISKpn28 family transposase | - |
| OOS97_RS25305 (OOS97_25305) | 39836..39997 | + | 162 | WP_004118124.1 | type I toxin-antitoxin system Hok family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(A) / aph(3')-Ia / aac(3)-IId / sul1 / qacE / aadA16 / dfrA27 / ARR-3 | pla | 1..315621 | 315621 | |
| - | flank | IS/Tn | - | - | 38685..39764 | 1079 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T264114 WP_004026354.1 NZ_CP110662:36008-36478 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT264114 WP_004026357.1 NZ_CP110662:35568-36011 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |