264113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4904732..4905542 Replicon chromosome
Accession NZ_CP110661
Organism Klebsiella pneumoniae strain B431

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag OOS97_RS23755 Protein ID WP_014908042.1
Coordinates 4905009..4905542 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag OOS97_RS23750 Protein ID WP_023343051.1
Coordinates 4904732..4904998 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOS97_RS23730 (4900603) 4900603..4900947 - 345 WP_004192220.1 cation efflux system protein CusF -
OOS97_RS23735 (4900965) 4900965..4902350 - 1386 WP_024623207.1 efflux transporter outer membrane subunit -
OOS97_RS23740 (4902523) 4902523..4903206 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
OOS97_RS23745 (4903196) 4903196..4904629 + 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
OOS97_RS23750 (4904732) 4904732..4904998 + 267 WP_023343051.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OOS97_RS23755 (4905009) 4905009..4905542 + 534 WP_014908042.1 type II toxin-antitoxin system toxin KacT Toxin
OOS97_RS23760 (4905590) 4905590..4906711 - 1122 WP_012737335.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T264113 WP_014908042.1 NZ_CP110661:4905009-4905542 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT264113 WP_023343051.1 NZ_CP110661:4904732-4904998 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure

References