264112

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4763553..4764069 Replicon chromosome
Accession NZ_CP110661
Organism Klebsiella pneumoniae strain B431

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OOS97_RS23215 Protein ID WP_002886902.1
Coordinates 4763785..4764069 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OOS97_RS23210 Protein ID WP_002886901.1
Coordinates 4763553..4763795 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOS97_RS23195 (4759581) 4759581..4760321 + 741 WP_002886899.1 KDGP aldolase family protein -
OOS97_RS23200 (4760388) 4760388..4761542 + 1155 WP_023302389.1 lactonase family protein -
OOS97_RS23205 (4761565) 4761565..4763475 + 1911 WP_009486549.1 PRD domain-containing protein -
OOS97_RS23210 (4763553) 4763553..4763795 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OOS97_RS23215 (4763785) 4763785..4764069 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OOS97_RS23220 (4764073) 4764073..4764537 - 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OOS97_RS23225 (4764846) 4764846..4766984 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OOS97_RS23230 (4767341) 4767341..4768084 - 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
OOS97_RS23235 (4768087) 4768087..4768260 - 174 WP_032410138.1 hypothetical protein -
OOS97_RS23240 (4768390) 4768390..4768653 + 264 WP_014908078.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T264112 WP_002886902.1 NZ_CP110661:4763785-4764069 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT264112 WP_002886901.1 NZ_CP110661:4763553-4763795 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References