264107

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3421286..3421943 Replicon chromosome
Accession NZ_CP110661
Organism Klebsiella pneumoniae strain B431

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OOS97_RS16685 Protein ID WP_002916310.1
Coordinates 3421286..3421696 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OOS97_RS16690 Protein ID WP_002916312.1
Coordinates 3421677..3421943 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOS97_RS16665 (3417286) 3417286..3419019 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
OOS97_RS16670 (3419025) 3419025..3419738 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OOS97_RS16675 (3419761) 3419761..3420657 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OOS97_RS16680 (3420758) 3420758..3421279 + 522 WP_002916308.1 flavodoxin FldB -
OOS97_RS16685 (3421286) 3421286..3421696 - 411 WP_002916310.1 protein YgfX Toxin
OOS97_RS16690 (3421677) 3421677..3421943 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OOS97_RS16695 (3422189) 3422189..3423172 + 984 WP_023342614.1 tRNA-modifying protein YgfZ -
OOS97_RS16700 (3423323) 3423323..3423982 - 660 WP_002916317.1 hemolysin III family protein -
OOS97_RS16705 (3424146) 3424146..3424457 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
OOS97_RS16710 (3424507) 3424507..3425235 + 729 WP_023342613.1 MurR/RpiR family transcriptional regulator -
OOS97_RS16715 (3425354) 3425354..3426787 + 1434 WP_265397530.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T264107 WP_002916310.1 NZ_CP110661:c3421696-3421286 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT264107 WP_002916312.1 NZ_CP110661:c3421943-3421677 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References