Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1651414..1653002 Replicon chromosome
Accession NZ_CP110661
Organism Klebsiella pneumoniae strain B431

Toxin (Protein)


Gene name hipA Uniprot ID A0A485W5A2
Locus tag OOS97_RS08005 Protein ID WP_023342812.1
Coordinates 1651680..1653002 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OOS97_RS08000 Protein ID WP_024622638.1
Coordinates 1651414..1651680 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOS97_RS07975 (1646565) 1646565..1647488 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
OOS97_RS07980 (1647469) 1647469..1648623 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OOS97_RS07985 (1648969) 1648969..1650348 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
OOS97_RS07990 (1650326) 1650326..1650826 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OOS97_RS07995 (1650823) 1650823..1651149 + 327 WP_004184023.1 hydroxyisourate hydrolase -
OOS97_RS08000 (1651414) 1651414..1651680 + 267 WP_024622638.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OOS97_RS08005 (1651680) 1651680..1653002 + 1323 WP_023342812.1 type II toxin-antitoxin system HipA family toxin Toxin
OOS97_RS08010 (1653019) 1653019..1654311 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OOS97_RS08015 (1654453) 1654453..1655457 - 1005 WP_004224758.1 fimbrial protein -
OOS97_RS08020 (1655445) 1655445..1657946 - 2502 WP_023342811.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5358

>T264102 WP_023342812.1 NZ_CP110661:1651680-1653002 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEVNAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9924.30 Da        Isoelectric Point: 8.5912

>AT264102 WP_024622638.1 NZ_CP110661:1651414-1651680 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYMKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A485W5A2

Antitoxin

Source ID Structure

References