264101

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 335667..336286 Replicon chromosome
Accession NZ_CP110661
Organism Klebsiella pneumoniae strain B431

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OOS97_RS01685 Protein ID WP_002892050.1
Coordinates 335667..335885 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OOS97_RS01690 Protein ID WP_002892066.1
Coordinates 335912..336286 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOS97_RS01650 (331714) 331714..331977 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
OOS97_RS01655 (331977) 331977..332117 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OOS97_RS01660 (332114) 332114..332812 - 699 WP_002892021.1 GNAT family protein -
OOS97_RS01665 (332913) 332913..334364 + 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
OOS97_RS01670 (334339) 334339..334809 - 471 WP_002892026.1 YlaC family protein -
OOS97_RS01675 (334830) 334830..334970 + 141 WP_004147370.1 hypothetical protein -
OOS97_RS01680 (334942) 334942..335508 - 567 WP_002892030.1 maltose O-acetyltransferase -
OOS97_RS01685 (335667) 335667..335885 - 219 WP_002892050.1 HHA domain-containing protein Toxin
OOS97_RS01690 (335912) 335912..336286 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OOS97_RS01695 (336772) 336772..339918 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
OOS97_RS01700 (339941) 339941..341134 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T264101 WP_002892050.1 NZ_CP110661:c335885-335667 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT264101 WP_002892066.1 NZ_CP110661:c336286-335912 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References