264099

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 4596723..4597245 Replicon chromosome
Accession NZ_CP110657
Organism Salmonella enterica subsp. enterica strain S2122

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag OOK64_RS22605 Protein ID WP_000221343.1
Coordinates 4596723..4597007 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag OOK64_RS22610 Protein ID WP_000885424.1
Coordinates 4596997..4597245 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOK64_RS22585 (4592798) 4592798..4594306 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
OOK64_RS22590 (4594351) 4594351..4594839 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
OOK64_RS22595 (4595032) 4595032..4596111 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
OOK64_RS22600 (4596163) 4596163..4596552 - 390 WP_000194089.1 RidA family protein -
OOK64_RS22605 (4596723) 4596723..4597007 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OOK64_RS22610 (4596997) 4596997..4597245 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OOK64_RS22615 (4597397) 4597397..4597612 + 216 WP_000206207.1 hypothetical protein -
OOK64_RS22620 (4597602) 4597602..4597934 + 333 WP_000253154.1 DUF1493 family protein -
OOK64_RS22625 (4598077) 4598077..4598985 + 909 WP_010989018.1 hypothetical protein -
OOK64_RS22630 (4599041) 4599041..4599755 - 715 Protein_4407 helix-turn-helix domain-containing protein -
OOK64_RS22635 (4600563) 4600563..4602029 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T264099 WP_000221343.1 NZ_CP110657:c4597007-4596723 [Salmonella enterica subsp. enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT264099 WP_000885424.1 NZ_CP110657:c4597245-4596997 [Salmonella enterica subsp. enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References