Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3548545..3549165 Replicon chromosome
Accession NZ_CP110657
Organism Salmonella enterica subsp. enterica strain S2122

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OOK64_RS17335 Protein ID WP_001280991.1
Coordinates 3548545..3548763 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OOK64_RS17340 Protein ID WP_000344807.1
Coordinates 3548791..3549165 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOK64_RS17295 (3543769) 3543769..3544338 + 570 WP_000779803.1 YbaY family lipoprotein -
OOK64_RS17300 (3544371) 3544371..3544760 - 390 WP_000961285.1 MGMT family protein -
OOK64_RS17310 (3544991) 3544991..3546541 - 1551 WP_000213139.1 EAL domain-containing protein -
OOK64_RS17315 (3546766) 3546766..3547026 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OOK64_RS17320 (3547032) 3547032..3547172 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OOK64_RS17325 (3547228) 3547228..3547698 - 471 WP_000136181.1 YlaC family protein -
OOK64_RS17330 (3547815) 3547815..3548366 - 552 WP_001278792.1 maltose O-acetyltransferase -
OOK64_RS17335 (3548545) 3548545..3548763 - 219 WP_001280991.1 HHA domain-containing protein Toxin
OOK64_RS17340 (3548791) 3548791..3549165 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OOK64_RS17345 (3549661) 3549661..3552810 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OOK64_RS17350 (3552833) 3552833..3554026 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T264098 WP_001280991.1 NZ_CP110657:c3548763-3548545 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT264098 WP_000344807.1 NZ_CP110657:c3549165-3548791 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References