264095

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2904743..2905319 Replicon chromosome
Accession NZ_CP110657
Organism Salmonella enterica subsp. enterica strain S2122

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag OOK64_RS14225 Protein ID WP_001131963.1
Coordinates 2904743..2905030 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag OOK64_RS14230 Protein ID WP_000063142.1
Coordinates 2905017..2905319 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOK64_RS14215 (2899853) 2899853..2903362 - 3510 WP_001043484.1 type I restriction-modification system endonuclease -
OOK64_RS14220 (2903560) 2903560..2904474 + 915 WP_000290512.1 restriction endonuclease -
OOK64_RS14225 (2904743) 2904743..2905030 + 288 WP_001131963.1 BrnT family toxin Toxin
OOK64_RS14230 (2905017) 2905017..2905319 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
OOK64_RS14235 (2905394) 2905394..2906350 - 957 WP_000187839.1 GTPase -
OOK64_RS14240 (2906361) 2906361..2906564 - 204 WP_000460616.1 YbdD/YjiX family protein -
OOK64_RS14245 (2906659) 2906659..2908809 - 2151 WP_000379927.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T264095 WP_001131963.1 NZ_CP110657:2904743-2905030 [Salmonella enterica subsp. enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT264095 WP_000063142.1 NZ_CP110657:2905017-2905319 [Salmonella enterica subsp. enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6PB01

References