Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2810542..2811058 Replicon chromosome
Accession NZ_CP110657
Organism Salmonella enterica subsp. enterica strain S2122

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag OOK64_RS13830 Protein ID WP_000220578.1
Coordinates 2810774..2811058 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag OOK64_RS13825 Protein ID WP_000212724.1
Coordinates 2810542..2810784 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOK64_RS13805 (2805562) 2805562..2806695 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
OOK64_RS13810 (2806679) 2806679..2807797 + 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
OOK64_RS13815 (2807794) 2807794..2808534 + 741 WP_000779263.1 KDGP aldolase family protein -
OOK64_RS13820 (2808551) 2808551..2810464 + 1914 WP_001212137.1 BglG family transcription antiterminator -
OOK64_RS13825 (2810542) 2810542..2810784 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OOK64_RS13830 (2810774) 2810774..2811058 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OOK64_RS13835 (2811062) 2811062..2811526 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OOK64_RS13840 (2811647) 2811647..2813785 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
OOK64_RS13845 (2814194) 2814194..2815846 - 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T264094 WP_000220578.1 NZ_CP110657:2810774-2811058 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT264094 WP_000212724.1 NZ_CP110657:2810542-2810784 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References