Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2600199..2600980 Replicon chromosome
Accession NZ_CP110657
Organism Salmonella enterica subsp. enterica strain S2122

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag OOK64_RS12725 Protein ID WP_000626099.1
Coordinates 2600489..2600980 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag OOK64_RS12720 Protein ID WP_001110452.1
Coordinates 2600199..2600492 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOK64_RS12690 (2596523) 2596523..2597428 + 906 WP_001268200.1 YjiK family protein -
OOK64_RS12695 (2597722) 2597722..2597991 - 270 WP_010989096.1 hypothetical protein -
OOK64_RS12700 (2597999) 2597999..2598214 - 216 WP_001595136.1 hypothetical protein -
OOK64_RS12705 (2598237) 2598237..2598524 - 288 WP_001269916.1 transcriptional regulator RtsB -
OOK64_RS12710 (2598521) 2598521..2599396 - 876 WP_000921674.1 AraC family transcriptional regulator -
OOK64_RS12715 (2599661) 2599661..2599882 - 222 WP_001576552.1 hypothetical protein -
OOK64_RS12720 (2600199) 2600199..2600492 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
OOK64_RS12725 (2600489) 2600489..2600980 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
OOK64_RS12730 (2601228) 2601228..2601980 - 753 WP_000842434.1 non-specific acid phosphatase -
OOK64_RS12735 (2602083) 2602083..2602157 - 75 Protein_2474 porin family protein -
OOK64_RS12740 (2603190) 2603190..2603567 - 378 WP_000916345.1 EthD family reductase -
OOK64_RS12745 (2603639) 2603639..2603971 + 333 WP_001165471.1 MerR family transcriptional regulator -
OOK64_RS12750 (2604062) 2604062..2604139 + 78 Protein_2477 helix-turn-helix domain-containing protein -
OOK64_RS12755 (2604330) 2604330..2605202 + 873 WP_033567082.1 ParA family protein -
OOK64_RS12760 (2605199) 2605199..2605555 + 357 WP_033567083.1 hypothetical protein -
OOK64_RS12765 (2605552) 2605552..2605794 + 243 WP_197603740.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T264093 WP_000626099.1 NZ_CP110657:2600489-2600980 [Salmonella enterica subsp. enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT264093 WP_001110452.1 NZ_CP110657:2600199-2600492 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References