264090

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1876280..1877040 Replicon chromosome
Accession NZ_CP110657
Organism Salmonella enterica subsp. enterica strain S2122

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag OOK64_RS09370 Protein ID WP_000533909.1
Coordinates 1876280..1876765 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag OOK64_RS09375 Protein ID WP_000965886.1
Coordinates 1876753..1877040 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOK64_RS09340 (1871350) 1871350..1872012 + 663 WP_000747548.1 OmpA family lipoprotein -
OOK64_RS09345 (1872231) 1872231..1873205 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
OOK64_RS09350 (1873255) 1873255..1873965 - 711 WP_000190524.1 DUF3053 domain-containing protein -
OOK64_RS09355 (1874404) 1874404..1874694 + 291 WP_000455790.1 HTH-type transcriptional regulator -
OOK64_RS09360 (1874983) 1874983..1875195 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
OOK64_RS09365 (1875369) 1875369..1875908 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
OOK64_RS09370 (1876280) 1876280..1876765 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
OOK64_RS09375 (1876753) 1876753..1877040 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
OOK64_RS09380 (1877218) 1877218..1877685 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
OOK64_RS09385 (1877857) 1877857..1878132 - 276 Protein_1833 IS3 family transposase -
OOK64_RS09390 (1878314) 1878314..1880383 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
OOK64_RS09395 (1880393) 1880393..1881304 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
OOK64_RS09400 (1881443) 1881443..1881745 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T264090 WP_000533909.1 NZ_CP110657:c1876765-1876280 [Salmonella enterica subsp. enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT264090 WP_000965886.1 NZ_CP110657:c1877040-1876753 [Salmonella enterica subsp. enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References