Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1244580..1245240 Replicon chromosome
Accession NZ_CP110657
Organism Salmonella enterica subsp. enterica strain S2122

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag OOK64_RS06305 Protein ID WP_000244756.1
Coordinates 1244580..1244993 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag OOK64_RS06310 Protein ID WP_000351186.1
Coordinates 1244974..1245240 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOK64_RS06285 (1240521) 1240521..1242254 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
OOK64_RS06290 (1242260) 1242260..1242973 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OOK64_RS06295 (1242997) 1242997..1243893 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
OOK64_RS06300 (1244006) 1244006..1244527 + 522 WP_001055885.1 flavodoxin FldB -
OOK64_RS06305 (1244580) 1244580..1244993 - 414 WP_000244756.1 protein YgfX Toxin
OOK64_RS06310 (1244974) 1244974..1245240 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
OOK64_RS06315 (1245490) 1245490..1246470 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
OOK64_RS06320 (1246586) 1246586..1247245 - 660 WP_000250289.1 hemolysin III family protein -
OOK64_RS06325 (1247409) 1247409..1247720 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
OOK64_RS06330 (1247879) 1247879..1249312 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T264087 WP_000244756.1 NZ_CP110657:c1244993-1244580 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT264087 WP_000351186.1 NZ_CP110657:c1245240-1244974 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References