264076

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4153967..4154607 Replicon chromosome
Accession NZ_CP110652
Organism Aeromonas salmonicida strain AS2

Toxin (Protein)


Gene name vagD Uniprot ID A0A807Z4U5
Locus tag ONZ63_RS19575 Protein ID WP_005320982.1
Coordinates 4154194..4154607 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A807Z5T0
Locus tag ONZ63_RS19570 Protein ID WP_005320985.1
Coordinates 4153967..4154197 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONZ63_RS19545 (ONZ63_19550) 4149943..4151334 + 1392 WP_034283822.1 T3SS effector protein-tyrosine-phosphatase AopH -
ONZ63_RS19550 (ONZ63_19555) 4151407..4151808 - 402 Protein_3771 IS4 family transposase -
ONZ63_RS19555 (ONZ63_19560) 4151876..4152793 + 918 WP_076611341.1 IS5-like element ISAs4 family transposase -
ONZ63_RS19560 (ONZ63_19565) 4153210..4153599 + 390 WP_139403308.1 site-specific integrase -
ONZ63_RS19565 (ONZ63_19570) 4153593..4153898 + 306 WP_225854310.1 integrase -
ONZ63_RS19570 (ONZ63_19575) 4153967..4154197 + 231 WP_005320985.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ONZ63_RS19575 (ONZ63_19580) 4154194..4154607 + 414 WP_005320982.1 PIN domain-containing protein Toxin
ONZ63_RS19580 (ONZ63_19585) 4154733..4155047 + 315 WP_225854525.1 hypothetical protein -
ONZ63_RS19585 (ONZ63_19590) 4155066..4155392 + 327 WP_271759635.1 hypothetical protein -
ONZ63_RS19590 (ONZ63_19595) 4155396..4156313 - 918 WP_076611341.1 IS5-like element ISAs4 family transposase -
ONZ63_RS19595 (ONZ63_19600) 4156548..4157466 - 919 Protein_3780 IS5-like element ISAs4 family transposase -
ONZ63_RS19600 (ONZ63_19605) 4157614..4158231 - 618 WP_225854306.1 subclass B2 metallo-beta-lactamase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - aopH 4141994..4157466 15472
- inside IScluster/Tn - aopH 4141994..4159703 17709
- inside Prophage - aerA/act / aopH 4141432..4157466 16034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14935.23 Da        Isoelectric Point: 5.7146

>T264076 WP_005320982.1 NZ_CP110652:4154194-4154607 [Aeromonas salmonicida]
VKTFMLDTCICSFIMREMPQSVLERLGAEVASGNRIVISAITYAEMRYGQIGKKASPKLGPAIDEFVRRLDGILPWDAAT
VDQTLEVRQQLAALGTPIGNNDAAIAAHALTAGCVLVTNNTREFSRVAGLLYEDWVH

Download         Length: 414 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8699.88 Da        Isoelectric Point: 4.7419

>AT264076 WP_005320985.1 NZ_CP110652:4153967-4154197 [Aeromonas salmonicida]
MRTVSIFKNGKNQAVRLPKDMEFQGVNDLEIIKNGDTITLRPARPDWFSLAECQKVDADFLQERTDVISDEGRFAL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807Z4U5

Antitoxin

Source ID Structure
AlphaFold DB A0A807Z5T0

References