Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4861153..4862726 Replicon chromosome
Accession NZ_CP110647
Organism Aeromonas salmonicida strain ZAS

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ONZ66_RS22665 Protein ID WP_271773953.1
Coordinates 4861153..4862472 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ONZ66_RS22670 Protein ID WP_017410478.1
Coordinates 4862472..4862726 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ONZ66_RS22655 (ONZ66_22660) 4859111..4859362 + 252 WP_271773952.1 phosphopantetheine-binding protein -
ONZ66_RS22660 (ONZ66_22665) 4859544..4860701 + 1158 WP_234592792.1 histidine decarboxylase -
ONZ66_RS22665 (ONZ66_22670) 4861153..4862472 - 1320 WP_271773953.1 type II toxin-antitoxin system HipA family toxin Toxin
ONZ66_RS22670 (ONZ66_22675) 4862472..4862726 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
ONZ66_RS22675 (ONZ66_22680) 4863265..4863888 + 624 WP_034524237.1 recombinase family protein -
ONZ66_RS22680 (ONZ66_22685) 4864657..4867122 + 2466 WP_271773954.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - basG 4859544..4877299 17755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49643.66 Da        Isoelectric Point: 7.0152

>T264072 WP_271773953.1 NZ_CP110647:c4862472-4861153 [Aeromonas salmonicida]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDETYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVLDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYIDGRWYLPLKATPTTHIIKLPIGKIESHSYSIDLSQSVENEYICTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGQASSKGRKYAIEQIFPRHFFQTAKTVGFERSAMEEILTELANAV
DDVIERVTRQLPADFPDAISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT264072 WP_017410478.1 NZ_CP110647:c4862726-4862472 [Aeromonas salmonicida]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References