Detailed information of TA system TA264070

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2355393..2357100
• Replicon: chromosome
• Accession: NZ_CP110645
• Organism: Aeromonas salmonicida strain AS3

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: ONZ54_RS11320
• Protein ID: WP_271788194.1
• Coordinates: 2355393..2356319 (-)
• Length: 309 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: ONZ54_RS11325
• Protein ID: WP_271788275.1
• Coordinates: 2356312..2357100 (-)
• Length: 263 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ONZ54_RS11300 (ONZ54_11310)	2351272..2352315	+	1044	WP_271788190.1	hypothetical protein	-
ONZ54_RS11305 (ONZ54_11315)	2352345..2352776	+	432	WP_271788191.1	hypothetical protein	-
ONZ54_RS11310 (ONZ54_11320)	2353204..2354265	+	1062	WP_271788192.1	site-specific DNA-methyltransferase	-
ONZ54_RS11315 (ONZ54_11325)	2354313..2355155	-	843	WP_271788193.1	HNH endonuclease signature motif containing protein	-
ONZ54_RS11320 (ONZ54_11330)	2355393..2356319	-	927	WP_271788194.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ONZ54_RS11325 (ONZ54_11335)	2356312..2357100	-	789	WP_271788275.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ONZ54_RS11330 (ONZ54_11340)	2357387..2357596	+	210	WP_271788195.1	hypothetical protein	-
ONZ54_RS11335 (ONZ54_11345)	2357599..2358090	+	492	WP_271788196.1	lysozyme	-
ONZ54_RS11340 (ONZ54_11350)	2358090..2358629	+	540	WP_271788197.1	DUF2514 family protein	-
ONZ54_RS11345 (ONZ54_11355)	2358717..2359097	+	381	WP_271788198.1	HNH endonuclease signature motif containing protein	-
ONZ54_RS11350 (ONZ54_11360)	2359247..2359678	+	432	WP_271788199.1	phage terminase small subunit P27 family	-
ONZ54_RS11355 (ONZ54_11365)	2359688..2361409	+	1722	WP_271788200.1	terminase large subunit	-
ONZ54_RS11360 (ONZ54_11370)	2361403..2361591	+	189	WP_033130572.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2317738..2395761	78023

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (16-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (2-97)

Sequences

Toxin

Protein

• Length: 309 a.a.
• Molecular weight: 34953.39 Da
• Isoelectric Point: 4.7745

>T264070 WP_271788194.1 NZ_CP110645:c2356319-2355393 [Aeromonas salmonicida]
MNKDSVYYRQVALLLKMLPIIANEKMFALKGGTAINLFVRDFPRLSVDIDLSYLPLEPREEAIANVRAALQRIVEQANSQ
KGLQARLQDNNGDELRIIVTGAATIKIELSPVARGTLHDPEVLPVVEDVETEFGYAEIAVVSMPDLYGGKLCAAMDRQHP
RDLFDVRMLLAAEGITREIFVGFLAYTLGHPRPISEVMDPRWKDLSDAFQQEFEGMTNEPVTLEELLEVPEAMFAALKAQ
FIPRDKDFLLSFKRGEPDWTLFDVPTAEQLPAIRWKLQNLQKLRDKNPEKHQEALVKLDNVLTTWLVK

Nucleotide

• Length: 927 bp

Antitoxin

Protein

• Length: 263 a.a.
• Molecular weight: 29728.81 Da
• Isoelectric Point: 9.3680

>AT264070 WP_271788275.1 NZ_CP110645:c2357100-2356312 [Aeromonas salmonicida]
ISSKINWLANHAPPGSLVLQPWLIENGISYSLASKYANSGWLKKMTNGVYYRPNPYQNSLPDWTDALAAITNQLNRHPHI
AGLTSLKYQGLSHYLQLGKEQVWLGGESKSSLPAWFREFDCSPWLFIGTSKLAEQSEKDFTLITVQGKELRASCPELAAY
EVVNAIGKHISFEHAAELFQGLTNLSPRKVQSILTRSKAVQTNRVFLFLSHYYRHQWTKRLDETQITLGTGKRQVVAQGR
LEPRYQITVPEPFFVASEIDHE

Nucleotide

• Length: 789 bp