Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5369807..5370432 Replicon chromosome
Accession NZ_CP110638
Organism Klebsiella pneumoniae strain K201054

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OO068_RS27180 Protein ID WP_002882817.1
Coordinates 5369807..5370190 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OO068_RS27185 Protein ID WP_004150355.1
Coordinates 5370190..5370432 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO068_RS27165 5367173..5368075 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OO068_RS27170 5368072..5368707 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OO068_RS27175 5368704..5369633 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OO068_RS27180 5369807..5370190 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OO068_RS27185 5370190..5370432 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OO068_RS27190 5370637..5371554 + 918 WP_012737090.1 alpha/beta hydrolase -
OO068_RS27195 5371568..5372509 - 942 WP_012543287.1 fatty acid biosynthesis protein FabY -
OO068_RS27200 5372554..5372991 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OO068_RS27205 5372988..5373848 - 861 WP_265390005.1 virulence factor BrkB family protein -
OO068_RS27210 5373842..5374441 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T264067 WP_002882817.1 NZ_CP110638:c5370190-5369807 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT264067 WP_004150355.1 NZ_CP110638:c5370432-5370190 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References