Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4889518..4890034 Replicon chromosome
Accession NZ_CP110638
Organism Klebsiella pneumoniae strain K201054

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OO068_RS24880 Protein ID WP_004178374.1
Coordinates 4889518..4889802 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OO068_RS24885 Protein ID WP_002886901.1
Coordinates 4889792..4890034 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO068_RS24855 4884914..4885222 - 309 WP_159224759.1 PTS sugar transporter subunit IIB -
OO068_RS24860 4885307..4885480 + 174 WP_004222159.1 hypothetical protein -
OO068_RS24865 4885483..4886226 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OO068_RS24870 4886583..4888721 + 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
OO068_RS24875 4889050..4889514 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OO068_RS24880 4889518..4889802 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO068_RS24885 4889792..4890034 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OO068_RS24890 4890112..4892022 - 1911 WP_009486549.1 PRD domain-containing protein -
OO068_RS24895 4892045..4893199 - 1155 WP_004178372.1 lactonase family protein -
OO068_RS24900 4893266..4894006 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T264065 WP_004178374.1 NZ_CP110638:c4889802-4889518 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT264065 WP_002886901.1 NZ_CP110638:c4890034-4889792 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References