Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2730741..2732329 Replicon chromosome
Accession NZ_CP110638
Organism Klebsiella pneumoniae strain K201054

Toxin (Protein)


Gene name hipA Uniprot ID A0A486JB51
Locus tag OO068_RS14505 Protein ID WP_023316847.1
Coordinates 2730741..2732063 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OO068_RS14510 Protein ID WP_004176198.1
Coordinates 2732063..2732329 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO068_RS14490 2725797..2728298 + 2502 WP_064153112.1 fimbria/pilus outer membrane usher protein -
OO068_RS14495 2728286..2729290 + 1005 WP_004176196.1 fimbrial protein -
OO068_RS14500 2729432..2730724 + 1293 WP_032414911.1 glycoside hydrolase family 10 protein -
OO068_RS14505 2730741..2732063 - 1323 WP_023316847.1 type II toxin-antitoxin system HipA family toxin Toxin
OO068_RS14510 2732063..2732329 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OO068_RS14515 2732716..2733042 - 327 WP_004224757.1 hydroxyisourate hydrolase -
OO068_RS14520 2733039..2733539 - 501 WP_130974846.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OO068_RS14525 2733517..2734896 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
OO068_RS14530 2735242..2736396 + 1155 WP_130974845.1 FAD-dependent urate hydroxylase HpxO -
OO068_RS14535 2736377..2737300 - 924 WP_004184020.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T264062 WP_023316847.1 NZ_CP110638:c2732063-2730741 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT264062 WP_004176198.1 NZ_CP110638:c2732329-2732063 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486JB51

Antitoxin

Source ID Structure

References