Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 199777..200516 Replicon chromosome
Accession NZ_CP110638
Organism Klebsiella pneumoniae strain K201054

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag OO068_RS01960 Protein ID WP_021312536.1
Coordinates 200031..200516 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag OO068_RS01955 Protein ID WP_003026799.1
Coordinates 199777..200043 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO068_RS01940 195280..197349 + 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -
OO068_RS01945 197646..199015 + 1370 WP_087830479.1 IS3 family transposase -
OO068_RS01950 199216..199644 + 429 WP_004901287.1 GFA family protein -
OO068_RS01955 199777..200043 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
OO068_RS01960 200031..200516 + 486 WP_021312536.1 GNAT family N-acetyltransferase Toxin
OO068_RS01965 200860..201012 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
OO068_RS01970 201314..202933 + 1620 WP_032415799.1 ABC-F family ATP-binding cassette domain-containing protein -
OO068_RS01975 203032..203244 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
OO068_RS01980 203497..203787 - 291 WP_002921931.1 HTH-type transcriptional regulator -
OO068_RS01985 204033..205388 - 1356 WP_032415797.1 aromatic acid/H+ symport family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 198290..199015 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17608.39 Da        Isoelectric Point: 10.3370

>T264054 WP_021312536.1 NZ_CP110638:200031-200516 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT264054 WP_003026799.1 NZ_CP110638:199777-200043 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References