Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 111355..112106 Replicon plasmid pA
Accession NZ_CP110637
Organism Klebsiella pneumoniae strain K201054

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag OO068_RS00620 Protein ID WP_048333033.1
Coordinates 111624..112106 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag OO068_RS00615 Protein ID WP_004902250.1
Coordinates 111355..111633 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO068_RS00590 107416..107898 + 483 WP_181947792.1 hypothetical protein -
OO068_RS00600 109353..109667 - 315 WP_048291862.1 hypothetical protein -
OO068_RS00605 110572..110913 + 342 WP_032437747.1 hypothetical protein -
OO068_RS00610 111021..111233 + 213 WP_016946198.1 hypothetical protein -
OO068_RS00615 111355..111633 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
OO068_RS00620 111624..112106 + 483 WP_048333033.1 GNAT family N-acetyltransferase Toxin
OO068_RS00625 112523..113491 + 969 WP_004225014.1 IS5 family transposase -
OO068_RS00630 113863..114186 + 324 WP_004902375.1 hypothetical protein -
OO068_RS00635 114335..115023 + 689 Protein_126 IS1 family transposase -
OO068_RS00640 115034..115300 + 267 Protein_127 IS3 family transposase -
OO068_RS00645 115370..116023 - 654 WP_023302796.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla / rmpA / rmpA / iroN / iroD / iroC / iroB / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS / iroN 1..204301 204301
- inside IScluster/Tn - pla 103583..115192 11609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17708.53 Da        Isoelectric Point: 8.9130

>T264052 WP_048333033.1 NZ_CP110637:111624-112106 [Klebsiella pneumoniae]
MGMRAPESLMSEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT264052 WP_004902250.1 NZ_CP110637:111355-111633 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References