Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3288932..3289552 Replicon chromosome
Accession NC_017265
Organism Yersinia pestis biovar Medievalis str. Harbin 35

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag YPC_RS15370 Protein ID WP_002208622.1
Coordinates 3289349..3289552 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag YPC_RS15365 Protein ID WP_002218472.1
Coordinates 3288932..3289300 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPC_RS15350 3287127..3287387 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
YPC_RS15355 3287403..3287546 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
YPC_RS15360 3288420..3288773 + 354 WP_002208619.1 hypothetical protein -
YPC_RS15365 3288932..3289300 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
YPC_RS15370 3289349..3289552 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
YPC_RS15375 3290440..3290829 + 390 WP_002208623.1 MGMT family protein -
YPC_RS15380 3290965..3291486 - 522 WP_002208624.1 lipoprotein -
YPC_RS15385 3291743..3292603 + 861 WP_002208625.1 acyl-CoA thioesterase II -
YPC_RS15390 3292863..3294152 - 1290 WP_002228344.1 ammonium transporter AmtB -
YPC_RS15395 3294192..3294530 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T26405 WP_002208622.1 NC_017265:3289349-3289552 [Yersinia pestis biovar Medievalis str. Harbin 35]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T26405 NC_017265:3289349-3289552 [Yersinia pestis biovar Medievalis str. Harbin 35]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT26405 WP_002218472.1 NC_017265:3288932-3289300 [Yersinia pestis biovar Medievalis str. Harbin 35]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT26405 NC_017265:3288932-3289300 [Yersinia pestis biovar Medievalis str. Harbin 35]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References