Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 24142..24946 Replicon plasmid pA
Accession NZ_CP110637
Organism Klebsiella pneumoniae strain K201054

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag OO068_RS00140 Protein ID WP_072198182.1
Coordinates 24419..24946 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag OO068_RS00135 Protein ID WP_048264996.1
Coordinates 24142..24411 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO068_RS00120 19395..20387 + 993 WP_135778242.1 ABC transporter substrate-binding protein -
OO068_RS00125 20384..21130 + 747 WP_048978068.1 ABC transporter permease -
OO068_RS00130 21145..23508 + 2364 WP_048264995.1 hypothetical protein -
OO068_RS00135 24142..24411 + 270 WP_048264996.1 DUF1778 domain-containing protein Antitoxin
OO068_RS00140 24419..24946 + 528 WP_072198182.1 GNAT family N-acetyltransferase Toxin
OO068_RS00145 25030..25338 + 309 WP_063444628.1 hypothetical protein -
OO068_RS00150 25389..26086 + 698 WP_265389984.1 IS1 family transposase -
OO068_RS00155 26398..27300 - 903 WP_048265000.1 LysR family transcriptional regulator -
OO068_RS00160 27398..28006 + 609 WP_023345578.1 short chain dehydrogenase -
OO068_RS00165 28125..29306 - 1182 WP_117107737.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla / rmpA / rmpA / iroN / iroD / iroC / iroB / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS / iroN 1..204301 204301
- flank IS/Tn - - 25583..26086 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(54-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 20078.04 Da        Isoelectric Point: 5.7389

>T264048 WP_072198182.1 NZ_CP110637:24419-24946 [Klebsiella pneumoniae]
VMQELAIEMINDEFDYDIGEFDCGEETLNTFLKDHLKRQHDGQILKGYVLVTKEQKPKLLGYYTLSGSCFERKMLPSKTQ
QRKIPYQNAPSITLGRLAIDKSIQGQGWGELLVTHAMNVVWDASKAVGIYGLFVEALNDKAKRFYTRLDFIQLVGENSNL
LFYPTKSIEKIFTEE

Download         Length: 528 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10148.65 Da        Isoelectric Point: 10.1733

>AT264048 WP_048264996.1 NZ_CP110637:24142-24411 [Klebsiella pneumoniae]
MSALRKQRIDLRLTDDDKSLIEEAAAMSNQTITQFVVASASERAAEVIEQHRRMVLNEESWNLVMDAIANPAAPNERLKR
AAKRLQKMR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References