Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 883798..884372 Replicon chromosome
Accession NZ_CP110621
Organism Pasteurella multocida strain P504190

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag OO004_RS04160 Protein ID WP_014667974.1
Coordinates 884088..884372 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag OO004_RS04155 Protein ID WP_014391174.1
Coordinates 883798..884091 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO004_RS04135 (OO004_04135) 878964..880055 - 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -
OO004_RS04140 (OO004_04140) 880404..882194 + 1791 WP_014391171.1 PTS ascorbate-specific subunit IIBC -
OO004_RS04145 (OO004_04145) 882239..882706 + 468 WP_014391172.1 PTS sugar transporter subunit IIA -
OO004_RS04150 (OO004_04150) 882724..883401 + 678 WP_014391173.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
OO004_RS04155 (OO004_04155) 883798..884091 - 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
OO004_RS04160 (OO004_04160) 884088..884372 - 285 WP_014667974.1 addiction module protein Toxin
OO004_RS04170 (OO004_04170) 885666..885927 - 262 Protein_791 hypothetical protein -
OO004_RS04175 (OO004_04175) 886271..886423 - 153 WP_014391177.1 hypothetical protein -
OO004_RS04180 (OO004_04180) 886723..887388 - 666 WP_265362905.1 hypothetical protein -
OO004_RS04185 (OO004_04185) 887403..888911 - 1509 WP_265362907.1 S8 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 885666..885827 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T264031 WP_014667974.1 NZ_CP110621:c884372-884088 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT264031 WP_014391174.1 NZ_CP110621:c884091-883798 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References