Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 731673..732274 Replicon chromosome
Accession NZ_CP110621
Organism Pasteurella multocida strain P504190

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag OO004_RS03455 Protein ID WP_078819687.1
Coordinates 731960..732274 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag OO004_RS03450 Protein ID WP_078819686.1
Coordinates 731673..731963 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO004_RS03420 (OO004_03420) 726898..727599 - 702 WP_014667788.1 phage antirepressor KilAC domain-containing protein -
OO004_RS03425 (OO004_03425) 727658..728110 - 453 WP_014390720.1 hypothetical protein -
OO004_RS03430 (OO004_03430) 728160..728357 - 198 WP_014390719.1 helix-turn-helix domain-containing protein -
OO004_RS03435 (OO004_03435) 728481..729158 + 678 WP_014390718.1 XRE family transcriptional regulator -
OO004_RS03440 (OO004_03440) 729369..731213 + 1845 WP_265362803.1 DEAD/DEAH box helicase family protein -
OO004_RS03445 (OO004_03445) 731243..731647 + 405 WP_146024473.1 hypothetical protein -
OO004_RS03450 (OO004_03450) 731673..731963 - 291 WP_078819686.1 putative addiction module antidote protein Antitoxin
OO004_RS03455 (OO004_03455) 731960..732274 - 315 WP_078819687.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO004_RS03460 (OO004_03460) 732732..732959 + 228 WP_099821843.1 hypothetical protein -
OO004_RS03475 (OO004_03475) 733855..734046 + 192 WP_014390714.1 hypothetical protein -
OO004_RS03480 (OO004_03480) 734021..734398 + 378 WP_014390713.1 hypothetical protein -
OO004_RS03485 (OO004_03485) 734509..735345 + 837 WP_014390712.1 KilA-N domain-containing protein -
OO004_RS03490 (OO004_03490) 735630..736286 + 657 WP_014390711.1 Bro-N domain-containing protein -
OO004_RS03495 (OO004_03495) 736690..737058 + 369 Protein_661 Bro-N domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 694225..747168 52943


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11763.65 Da        Isoelectric Point: 9.5553

>T264030 WP_078819687.1 NZ_CP110621:c732274-731960 [Pasteurella multocida]
MLDIIETTVFNKWLKELKDLSAKAAILARISRAKSGNFGDHKSVGDGLYEMRIMKGAGYRVYYAQYKDVTYLLICGGDKS
TQKADIAKAKALWEEIKQKEEINV

Download         Length: 315 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10574.22 Da        Isoelectric Point: 5.7134

>AT264030 WP_078819686.1 NZ_CP110621:c731963-731673 [Pasteurella multocida]
MSKKVELKPFDIAEYLDSEEMIAAYLSEILETGDTNEFISALGDVARARGMTELAAKTGLGRESLYKTLSHGSKPRFDTI
MKITQALGIKLVPTHI

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References