Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 731650..732251 Replicon chromosome
Accession NZ_CP110620
Organism Pasteurella multocida strain P5041881

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag OO003_RS03465 Protein ID WP_078819687.1
Coordinates 731937..732251 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag OO003_RS03460 Protein ID WP_078819686.1
Coordinates 731650..731940 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO003_RS03430 (OO003_03430) 726875..727576 - 702 WP_014667788.1 phage antirepressor KilAC domain-containing protein -
OO003_RS03435 (OO003_03435) 727635..728087 - 453 WP_014390720.1 hypothetical protein -
OO003_RS03440 (OO003_03440) 728137..728334 - 198 WP_014390719.1 helix-turn-helix domain-containing protein -
OO003_RS03445 (OO003_03445) 728458..729135 + 678 WP_014390718.1 XRE family transcriptional regulator -
OO003_RS03450 (OO003_03450) 729346..731190 + 1845 WP_265362803.1 DEAD/DEAH box helicase family protein -
OO003_RS03455 (OO003_03455) 731187..731624 + 438 WP_078819883.1 hypothetical protein -
OO003_RS03460 (OO003_03460) 731650..731940 - 291 WP_078819686.1 putative addiction module antidote protein Antitoxin
OO003_RS03465 (OO003_03465) 731937..732251 - 315 WP_078819687.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO003_RS03470 (OO003_03470) 732708..732935 + 228 WP_099821843.1 hypothetical protein -
OO003_RS03485 (OO003_03485) 733831..734022 + 192 WP_014390714.1 hypothetical protein -
OO003_RS03490 (OO003_03490) 733997..734374 + 378 WP_014390713.1 hypothetical protein -
OO003_RS03495 (OO003_03495) 734485..735321 + 837 WP_014390712.1 KilA-N domain-containing protein -
OO003_RS03500 (OO003_03500) 735606..736262 + 657 WP_014390711.1 Bro-N domain-containing protein -
OO003_RS03505 (OO003_03505) 736666..737034 + 369 Protein_663 Bro-N domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 694206..747142 52936


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11763.65 Da        Isoelectric Point: 9.5553

>T264027 WP_078819687.1 NZ_CP110620:c732251-731937 [Pasteurella multocida]
MLDIIETTVFNKWLKELKDLSAKAAILARISRAKSGNFGDHKSVGDGLYEMRIMKGAGYRVYYAQYKDVTYLLICGGDKS
TQKADIAKAKALWEEIKQKEEINV

Download         Length: 315 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10574.22 Da        Isoelectric Point: 5.7134

>AT264027 WP_078819686.1 NZ_CP110620:c731940-731650 [Pasteurella multocida]
MSKKVELKPFDIAEYLDSEEMIAAYLSEILETGDTNEFISALGDVARARGMTELAAKTGLGRESLYKTLSHGSKPRFDTI
MKITQALGIKLVPTHI

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References