Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3831987..3832672 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID P9WF49
Locus tag M7V54_RS18085 Protein ID WP_003917170.1
Coordinates 3832262..3832672 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M7V54_RS18080 Protein ID WP_003912220.1
Coordinates 3831987..3832265 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS18060 3827976..3829577 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
M7V54_RS18065 3829594..3830298 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
M7V54_RS18070 3830416..3830982 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
M7V54_RS18075 3831044..3831931 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
M7V54_RS18080 3831987..3832265 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M7V54_RS18085 3832262..3832672 + 411 WP_003917170.1 type II toxin-antitoxin system VapC family toxin Toxin
M7V54_RS18090 3832705..3834441 - 1737 WP_003418002.1 cholesterol oxidase -
M7V54_RS18095 3834497..3835624 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
M7V54_RS18100 3835644..3837233 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14669.76 Da        Isoelectric Point: 5.1784

>T264026 WP_003917170.1 NZ_CP110619:3832262-3832672 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVESMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT264026 WP_003912220.1 NZ_CP110619:3831987-3832265 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A5U883

Antitoxin

Source ID Structure

References