Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3776478..3777007 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag M7V54_RS17825 Protein ID WP_003417760.1
Coordinates 3776750..3777007 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag M7V54_RS17820 Protein ID WP_003417757.1
Coordinates 3776478..3776753 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS17785 3773051..3773740 - 690 WP_003917774.1 BBE domain-containing protein -
M7V54_RS17790 3773927..3774298 - 372 WP_003417739.1 FAD-binding protein -
M7V54_RS17795 3774196..3774414 - 219 WP_157132559.1 hypothetical protein -
M7V54_RS17800 3774441..3774701 - 261 WP_003417741.1 hypothetical protein -
M7V54_RS17805 3774816..3775205 + 390 WP_003417745.1 DUF732 domain-containing protein -
M7V54_RS17810 3775219..3775512 - 294 WP_003417749.1 DUF3017 domain-containing protein -
M7V54_RS17815 3775509..3776354 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
M7V54_RS17820 3776478..3776753 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
M7V54_RS17825 3776750..3777007 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
M7V54_RS17830 3777049..3778239 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
M7V54_RS17835 3778356..3778724 + 369 WP_003417765.1 FHA domain-containing protein -
M7V54_RS17840 3778721..3779272 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
M7V54_RS17845 3779279..3779860 - 582 WP_003417769.1 ATP/GTP-binding protein -
M7V54_RS17850 3779841..3780209 - 369 WP_003417772.1 DUF742 domain-containing protein -
M7V54_RS17855 3780187..3780579 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T264024 WP_003417760.1 NZ_CP110619:3776750-3777007 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT264024 WP_003417757.1 NZ_CP110619:3776478-3776753 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References