264018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 3137348..3139122 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name abiEi Uniprot ID P71626
Locus tag M7V54_RS14995 Protein ID WP_003414409.1
Coordinates 3137348..3138232 (-) Length 295 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID P71625
Locus tag M7V54_RS15000 Protein ID WP_003414414.1
Coordinates 3138235..3139122 (-) Length 296 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS14975 3132612..3132986 - 375 WP_003414296.1 type III-A CRISPR-associated protein Csm2 -
M7V54_RS14980 3132983..3135412 - 2430 WP_003911999.1 type III-A CRISPR-associated protein Cas10/Csm1 -
M7V54_RS14985 3135409..3136197 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
M7V54_RS14990 3136531..3137076 - 546 WP_003913758.1 DUF1802 family protein -
M7V54_RS14995 3137348..3138232 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M7V54_RS15000 3138235..3139122 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M7V54_RS15005 3139427..3139972 - 546 WP_003899500.1 DUF1802 family protein -
M7V54_RS15010 3139969..3140238 - 270 WP_003414489.1 DUF2277 family protein -
M7V54_RS15015 3140259..3140651 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin -
M7V54_RS15020 3140648..3140863 - 216 WP_003912003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M7V54_RS15025 3140910..3141659 + 750 WP_003414497.1 enoyl-CoA hydratase -
M7V54_RS15030 3141738..3142820 - 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-272)

Antitoxin

AbiEi antitoxin C-terminal domain

(84-237)


Sequences

Toxin        


Download         Length: 295 a.a.        Molecular weight: 33056.72 Da        Isoelectric Point: 7.1520

>T264018 WP_003414409.1 NZ_CP110619:c3138232-3137348 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS

Download         Length: 885 bp

Antitoxin


Download         Length: 296 a.a.        Molecular weight: 32315.19 Da        Isoelectric Point: 9.4723

>AT264018 WP_003414414.1 NZ_CP110619:c3139122-3138235 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA

Download         Length: 888 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6Y56

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBU9

References