Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3113806..3114376 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag M7V54_RS14870 Protein ID WP_003414166.1
Coordinates 3113806..3114162 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag M7V54_RS14875 Protein ID WP_003901465.1
Coordinates 3114146..3114376 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS14850 3109258..3110946 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
M7V54_RS14855 3110950..3111276 - 327 WP_003414157.1 hypothetical protein -
M7V54_RS14860 3111449..3112036 + 588 WP_003914429.1 DUF3558 family protein -
M7V54_RS14865 3112055..3113704 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
M7V54_RS14870 3113806..3114162 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
M7V54_RS14875 3114146..3114376 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
M7V54_RS14880 3114419..3115462 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
M7V54_RS14885 3115461..3115928 + 468 WP_003414177.1 DUF1778 domain-containing protein -
M7V54_RS14890 3116104..3116358 - 255 WP_003917684.1 hypothetical protein -
M7V54_RS14895 3116506..3116910 + 405 WP_009938577.1 hypothetical protein -
M7V54_RS14900 3116907..3117098 + 192 WP_003414184.1 hypothetical protein -
M7V54_RS14905 3117315..3117575 + 261 Protein_2942 transposase -
M7V54_RS14910 3118685..3118942 + 258 WP_003899489.1 hypothetical protein -
M7V54_RS14915 3119047..3119358 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T264017 WP_003414166.1 NZ_CP110619:c3114162-3113806 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT264017 WP_003901465.1 NZ_CP110619:c3114376-3114146 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References