Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2873366..2874003 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag M7V54_RS13550 Protein ID WP_003413180.1
Coordinates 2873366..2873761 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag M7V54_RS13555 Protein ID WP_003413183.1
Coordinates 2873758..2874003 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS13510 2868769..2869980 + 1212 WP_009936235.1 alpha/beta hydrolase family protein -
M7V54_RS13515 2870107..2870766 + 660 WP_003900846.1 LppA family lipoprotein -
M7V54_RS13520 2870763..2871425 + 663 WP_003900848.1 LppA family lipoprotein -
M7V54_RS13525 2871422..2871700 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
M7V54_RS13530 2871793..2872206 + 414 WP_003413164.1 PIN domain nuclease -
M7V54_RS13535 2872245..2872502 + 258 WP_003413167.1 CopG family transcriptional regulator -
M7V54_RS13540 2872499..2872876 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
M7V54_RS13545 2872892..2873266 - 375 WP_003413177.1 hypothetical protein -
M7V54_RS13550 2873366..2873761 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
M7V54_RS13555 2873758..2874003 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
M7V54_RS13560 2874414..2874833 - 420 WP_003413190.1 A24 family peptidase -
M7V54_RS13565 2874845..2875654 - 810 WP_003413193.1 shikimate dehydrogenase -
M7V54_RS13570 2875651..2876904 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
M7V54_RS13575 2876897..2877409 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T264012 WP_003413180.1 NZ_CP110619:c2873761-2873366 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT264012 WP_003413183.1 NZ_CP110619:c2874003-2873758 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References