Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 2857906..2858546 | Replicon | chromosome |
Accession | NZ_CP110619 | ||
Organism | Mycobacterium tuberculosis strain H37Rv-1 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ08 |
Locus tag | M7V54_RS13445 | Protein ID | WP_003412970.1 |
Coordinates | 2857906..2858325 (-) | Length | 140 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TQ09 |
Locus tag | M7V54_RS13450 | Protein ID | WP_003412975.1 |
Coordinates | 2858322..2858546 (-) | Length | 75 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M7V54_RS13415 | 2853491..2854213 | - | 723 | WP_003412957.1 | DUF1906 domain-containing protein | - |
M7V54_RS13420 | 2854730..2854957 | + | 228 | WP_003412960.1 | type II toxin-antitoxin system VapB family antitoxin | - |
M7V54_RS13425 | 2854954..2855355 | + | 402 | WP_003412963.1 | PIN domain-containing protein | - |
M7V54_RS13430 | 2855390..2856310 | - | 921 | WP_003412965.1 | restriction endonuclease | - |
M7V54_RS13435 | 2856651..2856896 | - | 246 | WP_071854223.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
M7V54_RS13440 | 2856955..2857905 | + | 951 | WP_003911916.1 | ERCC4 domain-containing protein | - |
M7V54_RS13445 | 2857906..2858325 | - | 420 | WP_003412970.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
M7V54_RS13450 | 2858322..2858546 | - | 225 | WP_003412975.1 | antitoxin VapB39 | Antitoxin |
M7V54_RS13455 | 2858577..2861420 | - | 2844 | WP_003899363.1 | aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme | - |
M7V54_RS13460 | 2861492..2861893 | - | 402 | WP_003412981.1 | hypothetical protein | - |
M7V54_RS13465 | 2861893..2862363 | - | 471 | WP_003899364.1 | transcription antitermination factor NusB | - |
M7V54_RS13470 | 2862366..2862929 | - | 564 | WP_003412989.1 | elongation factor P | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 14732.70 Da Isoelectric Point: 6.7519
>T264009 WP_003412970.1 NZ_CP110619:c2858325-2857906 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL
Download Length: 420 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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