Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2811722..2812374 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag M7V54_RS13250 Protein ID WP_003412752.1
Coordinates 2811949..2812374 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag M7V54_RS13245 Protein ID WP_003412749.1
Coordinates 2811722..2811943 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS13230 2809962..2810168 - 207 WP_003899347.1 hypothetical protein -
M7V54_RS13235 2810304..2810927 + 624 WP_003900858.1 TIGR00725 family protein -
M7V54_RS13240 2810917..2811669 + 753 WP_003900859.1 hypothetical protein -
M7V54_RS13245 2811722..2811943 + 222 WP_003412749.1 antitoxin Antitoxin
M7V54_RS13250 2811949..2812374 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
M7V54_RS13255 2812397..2813578 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
M7V54_RS13260 2813575..2814621 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
M7V54_RS13265 2814632..2815735 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
M7V54_RS13270 2815994..2816815 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
M7V54_RS13275 2816812..2817369 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T264008 WP_003412752.1 NZ_CP110619:2811949-2812374 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT264008 WP_003412749.1 NZ_CP110619:2811722-2811943 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References