Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2365659..2366354 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag M7V54_RS11105 Protein ID WP_003410811.1
Coordinates 2365659..2366093 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag M7V54_RS11110 Protein ID WP_003410814.1
Coordinates 2366100..2366354 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS11095 2361813..2364854 + 3042 WP_003911743.1 DEAD/DEAH box helicase -
M7V54_RS11100 2364847..2365680 + 834 WP_003899172.1 SWIM zinc finger family protein -
M7V54_RS11105 2365659..2366093 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
M7V54_RS11110 2366100..2366354 - 255 WP_003410814.1 antitoxin Antitoxin
M7V54_RS11115 2366370..2366627 - 258 WP_003410816.1 hypothetical protein -
M7V54_RS11120 2367038..2368299 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
M7V54_RS11125 2368932..2369228 + 297 WP_003410820.1 PE family protein -
M7V54_RS11130 2369284..2370015 + 732 WP_003900467.1 PPE family protein -
M7V54_RS11135 2370556..2371302 - 747 WP_003906749.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T264006 WP_003410811.1 NZ_CP110619:c2366093-2365659 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT264006 WP_003410814.1 NZ_CP110619:c2366354-2366100 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References