Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2259618..2260244 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag M7V54_RS10625 Protein ID WP_003410075.1
Coordinates 2259846..2260244 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag M7V54_RS10620 Protein ID WP_003911750.1
Coordinates 2259618..2259845 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS10610 2257657..2258001 - 345 WP_003410065.1 ferredoxin family protein -
M7V54_RS10615 2258190..2259359 - 1170 WP_003899126.1 ATP-binding protein -
M7V54_RS10620 2259618..2259845 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M7V54_RS10625 2259846..2260244 + 399 WP_003410075.1 PIN domain nuclease Toxin
M7V54_RS10630 2260427..2260858 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
M7V54_RS10635 2260959..2261393 + 435 WP_003914358.1 DUF1398 domain-containing protein -
M7V54_RS10640 2261830..2262009 - 180 Protein_2103 hypothetical protein -
M7V54_RS10645 2262103..2262717 + 615 WP_234715470.1 IS110 family transposase -
M7V54_RS10650 2262671..2263261 + 591 WP_003899131.1 IS110 family transposase -
M7V54_RS10655 2263389..2264645 - 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T264003 WP_003410075.1 NZ_CP110619:2259846-2260244 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT264003 WP_003911750.1 NZ_CP110619:2259618-2259845 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References