Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2235878..2236464 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag M7V54_RS10520 Protein ID WP_003410010.1
Coordinates 2235878..2236222 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag M7V54_RS10525 Protein ID WP_003410014.1
Coordinates 2236216..2236464 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS10485 2231584..2232183 + 600 WP_003409989.1 L-lysine exporter -
M7V54_RS10490 2232599..2233027 + 429 WP_003409992.1 cellulose-binding protein -
M7V54_RS10495 2233253..2233792 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
M7V54_RS10500 2234312..2234872 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
M7V54_RS10505 2234869..2235210 - 342 WP_003410003.1 DUF2384 domain-containing protein -
M7V54_RS10510 2235296..2235553 + 258 WP_003410006.1 hypothetical protein -
M7V54_RS10515 2235454..2235789 - 336 WP_003410009.1 dehydrogenase -
M7V54_RS10520 2235878..2236222 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
M7V54_RS10525 2236216..2236464 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
M7V54_RS10530 2236564..2238879 - 2316 WP_003899120.1 cation transporter ATPase CptG -
M7V54_RS10535 2238876..2239148 - 273 WP_003410017.1 DUF1490 family protein -
M7V54_RS10540 2239201..2239557 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
M7V54_RS10545 2239714..2240481 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T264002 WP_003410010.1 NZ_CP110619:c2236222-2235878 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT264002 WP_003410014.1 NZ_CP110619:c2236464-2236216 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References