Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2234312..2235210 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag M7V54_RS10500 Protein ID WP_003410001.1
Coordinates 2234312..2234872 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag M7V54_RS10505 Protein ID WP_003410003.1
Coordinates 2234869..2235210 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS10470 2229481..2230134 - 654 WP_003409976.1 cutinase Cfp21 -
M7V54_RS10475 2230249..2230479 + 231 WP_003409980.1 DUF167 domain-containing protein -
M7V54_RS10480 2230564..2231475 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M7V54_RS10485 2231584..2232183 + 600 WP_003409989.1 L-lysine exporter -
M7V54_RS10490 2232599..2233027 + 429 WP_003409992.1 cellulose-binding protein -
M7V54_RS10495 2233253..2233792 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
M7V54_RS10500 2234312..2234872 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
M7V54_RS10505 2234869..2235210 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
M7V54_RS10510 2235296..2235553 + 258 WP_003410006.1 hypothetical protein -
M7V54_RS10515 2235454..2235789 - 336 WP_003410009.1 dehydrogenase -
M7V54_RS10520 2235878..2236222 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
M7V54_RS10525 2236216..2236464 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
M7V54_RS10530 2236564..2238879 - 2316 WP_003899120.1 cation transporter ATPase CptG -
M7V54_RS10535 2238876..2239148 - 273 WP_003410017.1 DUF1490 family protein -
M7V54_RS10540 2239201..2239557 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T264001 WP_003410001.1 NZ_CP110619:c2234872-2234312 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT264001 WP_003410003.1 NZ_CP110619:c2235210-2234869 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References