Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mbcAT/RES-TIGR02293 |
Location | 2234312..2235210 | Replicon | chromosome |
Accession | NZ_CP110619 | ||
Organism | Mycobacterium tuberculosis strain H37Rv-1 |
Toxin (Protein)
Gene name | mbcT | Uniprot ID | P64908 |
Locus tag | M7V54_RS10500 | Protein ID | WP_003410001.1 |
Coordinates | 2234312..2234872 (-) | Length | 187 a.a. |
Antitoxin (Protein)
Gene name | mbcA | Uniprot ID | P64910 |
Locus tag | M7V54_RS10505 | Protein ID | WP_003410003.1 |
Coordinates | 2234869..2235210 (-) | Length | 114 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M7V54_RS10470 | 2229481..2230134 | - | 654 | WP_003409976.1 | cutinase Cfp21 | - |
M7V54_RS10475 | 2230249..2230479 | + | 231 | WP_003409980.1 | DUF167 domain-containing protein | - |
M7V54_RS10480 | 2230564..2231475 | - | 912 | WP_003409986.1 | ArgP/LysG family DNA-binding transcriptional regulator | - |
M7V54_RS10485 | 2231584..2232183 | + | 600 | WP_003409989.1 | L-lysine exporter | - |
M7V54_RS10490 | 2232599..2233027 | + | 429 | WP_003409992.1 | cellulose-binding protein | - |
M7V54_RS10495 | 2233253..2233792 | + | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
M7V54_RS10500 | 2234312..2234872 | - | 561 | WP_003410001.1 | RES family NAD+ phosphorylase | Toxin |
M7V54_RS10505 | 2234869..2235210 | - | 342 | WP_003410003.1 | DUF2384 domain-containing protein | Antitoxin |
M7V54_RS10510 | 2235296..2235553 | + | 258 | WP_003410006.1 | hypothetical protein | - |
M7V54_RS10515 | 2235454..2235789 | - | 336 | WP_003410009.1 | dehydrogenase | - |
M7V54_RS10520 | 2235878..2236222 | - | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | - |
M7V54_RS10525 | 2236216..2236464 | - | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | - |
M7V54_RS10530 | 2236564..2238879 | - | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
M7V54_RS10535 | 2238876..2239148 | - | 273 | WP_003410017.1 | DUF1490 family protein | - |
M7V54_RS10540 | 2239201..2239557 | - | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 187 a.a. Molecular weight: 20248.70 Da Isoelectric Point: 4.5091
>T264001 WP_003410001.1 NZ_CP110619:c2234872-2234312 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT
Download Length: 561 bp
Antitoxin
Download Length: 114 a.a. Molecular weight: 12488.33 Da Isoelectric Point: 4.8359
>AT264001 WP_003410003.1 NZ_CP110619:c2235210-2234869 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV
Download Length: 342 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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