Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 2226986..2227674 | Replicon | chromosome |
Accession | NZ_CP110619 | ||
Organism | Mycobacterium tuberculosis strain H37Rv-1 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P0A653 |
Locus tag | M7V54_RS10455 | Protein ID | WP_003409958.1 |
Coordinates | 2226986..2227405 (-) | Length | 140 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ28 |
Locus tag | M7V54_RS10460 | Protein ID | WP_003409968.1 |
Coordinates | 2227414..2227674 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M7V54_RS10435 | 2222481..2223329 | + | 849 | WP_003409942.1 | class I SAM-dependent methyltransferase | - |
M7V54_RS10440 | 2223292..2224737 | - | 1446 | WP_003899115.1 | APC family permease | - |
M7V54_RS10445 | 2224916..2225602 | - | 687 | WP_003409954.1 | immunoprotective protein Mpt64 | - |
M7V54_RS10450 | 2225793..2226761 | - | 969 | WP_003899116.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
M7V54_RS10455 | 2226986..2227405 | - | 420 | WP_003409958.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
M7V54_RS10460 | 2227414..2227674 | - | 261 | WP_003409968.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
M7V54_RS10465 | 2227817..2229493 | + | 1677 | WP_003899118.1 | PecA family PE domain-processing aspartic protease | - |
M7V54_RS10470 | 2229481..2230134 | - | 654 | WP_003409976.1 | cutinase Cfp21 | - |
M7V54_RS10475 | 2230249..2230479 | + | 231 | WP_003409980.1 | DUF167 domain-containing protein | - |
M7V54_RS10480 | 2230564..2231475 | - | 912 | WP_003409986.1 | ArgP/LysG family DNA-binding transcriptional regulator | - |
M7V54_RS10485 | 2231584..2232183 | + | 600 | WP_003409989.1 | L-lysine exporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 14724.89 Da Isoelectric Point: 7.9535
>T264000 WP_003409958.1 NZ_CP110619:c2227405-2226986 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA
Download Length: 420 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C4H9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C483 |