Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2226986..2227674 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag M7V54_RS10455 Protein ID WP_003409958.1
Coordinates 2226986..2227405 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag M7V54_RS10460 Protein ID WP_003409968.1
Coordinates 2227414..2227674 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS10435 2222481..2223329 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
M7V54_RS10440 2223292..2224737 - 1446 WP_003899115.1 APC family permease -
M7V54_RS10445 2224916..2225602 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
M7V54_RS10450 2225793..2226761 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
M7V54_RS10455 2226986..2227405 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
M7V54_RS10460 2227414..2227674 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M7V54_RS10465 2227817..2229493 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
M7V54_RS10470 2229481..2230134 - 654 WP_003409976.1 cutinase Cfp21 -
M7V54_RS10475 2230249..2230479 + 231 WP_003409980.1 DUF167 domain-containing protein -
M7V54_RS10480 2230564..2231475 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M7V54_RS10485 2231584..2232183 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T264000 WP_003409958.1 NZ_CP110619:c2227405-2226986 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT264000 WP_003409968.1 NZ_CP110619:c2227674-2227414 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References