Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2196216..2196919 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag M7V54_RS10245 Protein ID WP_003409778.1
Coordinates 2196216..2196545 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag M7V54_RS10250 Protein ID WP_003409780.1
Coordinates 2196542..2196919 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS10225 2192599..2193669 + 1071 WP_003899091.1 epoxide hydrolase EphB -
M7V54_RS10230 2193666..2194181 + 516 WP_003409718.1 flavin reductase family protein -
M7V54_RS10235 2194178..2195239 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
M7V54_RS10240 2195236..2196006 + 771 WP_003409775.1 SDR family oxidoreductase -
M7V54_RS10245 2196216..2196545 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M7V54_RS10250 2196542..2196919 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
M7V54_RS10255 2196916..2197506 - 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
M7V54_RS10260 2197561..2198925 + 1365 WP_003903691.1 HNH endonuclease signature motif containing protein -
M7V54_RS10265 2199080..2199532 - 453 WP_003899095.1 lipoprotein -
M7V54_RS10270 2199596..2199997 + 402 WP_003409869.1 hypothetical protein -
M7V54_RS10275 2199990..2200172 - 183 WP_003409870.1 hypothetical protein -
M7V54_RS10280 2200286..2200636 - 351 WP_003899096.1 hypothetical protein -
M7V54_RS10285 2200647..2201549 - 903 WP_003899097.1 hypothetical protein -
M7V54_RS10290 2201570..2201761 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T263997 WP_003409778.1 NZ_CP110619:c2196545-2196216 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT263997 WP_003409780.1 NZ_CP110619:c2196919-2196542 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References