Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1967919..1968379 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag M7V54_RS09230 Protein ID WP_003898996.1
Coordinates 1968131..1968379 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag M7V54_RS09225 Protein ID WP_003408528.1
Coordinates 1967919..1968131 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS09210 1964397..1965584 - 1188 WP_003898992.1 nitrate transporter NarK -
M7V54_RS09215 1965871..1966155 + 285 WP_003408522.1 DUF1876 domain-containing protein -
M7V54_RS09220 1966169..1967851 - 1683 WP_003916850.1 SulP family inorganic anion transporter -
M7V54_RS09225 1967919..1968131 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M7V54_RS09230 1968131..1968379 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
M7V54_RS09235 1968387..1969124 + 738 WP_003898997.1 hypothetical protein -
M7V54_RS09240 1969218..1970918 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
M7V54_RS09245 1971203..1971604 - 402 WP_003408538.1 hypothetical protein -
M7V54_RS09250 1971594..1972205 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T263996 WP_003898996.1 NZ_CP110619:1968131-1968379 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT263996 WP_003408528.1 NZ_CP110619:1967919-1968131 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References