Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1947244..1947857 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag M7V54_RS09120 Protein ID WP_003408465.1
Coordinates 1947244..1947633 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag M7V54_RS09125 Protein ID WP_003408469.1
Coordinates 1947630..1947857 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS09085 1942873..1943787 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
M7V54_RS09090 1943790..1944620 + 831 WP_003916848.1 cyclase family protein -
M7V54_RS09095 1944620..1944970 + 351 WP_003898986.1 cupin domain-containing protein -
M7V54_RS09100 1945023..1945841 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
M7V54_RS09105 1945855..1946634 + 780 WP_003408460.1 IclR family transcriptional regulator -
M7V54_RS09115 1947065..1947196 + 132 Protein_1798 IS3 family transposase -
M7V54_RS09120 1947244..1947633 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
M7V54_RS09125 1947630..1947857 - 228 WP_003408469.1 antitoxin Antitoxin
M7V54_RS09130 1948075..1949559 + 1485 WP_003408473.1 biotin carboxylase -
M7V54_RS09135 1949556..1950803 + 1248 WP_003408476.1 serine hydrolase -
M7V54_RS09140 1950846..1951265 - 420 WP_003408483.1 hypothetical protein -
M7V54_RS09145 1951255..1951965 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T263995 WP_003408465.1 NZ_CP110619:c1947633-1947244 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT263995 WP_003408469.1 NZ_CP110619:c1947857-1947630 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References