Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1764983..1765596 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag M7V54_RS08300 Protein ID WP_003407786.1
Coordinates 1765192..1765596 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag M7V54_RS08295 Protein ID WP_009935474.1
Coordinates 1764983..1765186 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS08265 1760388..1760768 + 381 WP_003916859.1 fumarate reductase subunit C -
M7V54_RS08270 1760765..1761142 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
M7V54_RS08275 1761210..1761818 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
M7V54_RS08280 1761996..1763150 + 1155 Protein_1633 MMPL family transporter -
M7V54_RS08285 1763160..1763606 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
M7V54_RS08290 1763641..1764930 + 1290 WP_003407781.1 threonine ammonia-lyase -
M7V54_RS08295 1764983..1765186 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M7V54_RS08300 1765192..1765596 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
M7V54_RS08305 1765613..1767355 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
M7V54_RS08310 1767348..1769645 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T263994 WP_003407786.1 NZ_CP110619:1765192-1765596 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT263994 WP_009935474.1 NZ_CP110619:1764983-1765186 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References