Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1686484..1687100 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag M7V54_RS07955 Protein ID WP_003407593.1
Coordinates 1686783..1687100 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag M7V54_RS07950 Protein ID WP_003900349.1
Coordinates 1686484..1686786 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS07940 1682370..1684217 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
M7V54_RS07945 1684218..1686470 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
M7V54_RS07950 1686484..1686786 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
M7V54_RS07955 1686783..1687100 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
M7V54_RS07960 1687097..1688101 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
M7V54_RS07965 1688154..1689443 + 1290 WP_003407599.1 serine hydrolase domain-containing protein -
M7V54_RS07970 1689516..1690241 - 726 WP_023641476.1 class I SAM-dependent methyltransferase -
M7V54_RS07975 1690347..1690559 - 213 WP_003898900.1 dodecin family protein -
M7V54_RS07980 1690620..1691018 + 399 WP_003900351.1 hypothetical protein -
M7V54_RS07985 1691063..1692091 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T263993 WP_003407593.1 NZ_CP110619:1686783-1687100 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT263993 WP_003900349.1 NZ_CP110619:1686484-1686786 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References