Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1388691..1389250 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag M7V54_RS06650 Protein ID WP_003898789.1
Coordinates 1388691..1388984 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag M7V54_RS06655 Protein ID WP_003406322.1
Coordinates 1388981..1389250 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS06625 1384284..1384544 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
M7V54_RS06630 1384541..1384972 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
M7V54_RS06635 1384995..1386683 - 1689 WP_003910308.1 PE family protein -
M7V54_RS06640 1386863..1387723 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
M7V54_RS06645 1387804..1388634 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
M7V54_RS06650 1388691..1388984 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
M7V54_RS06655 1388981..1389250 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M7V54_RS06660 1389363..1393058 - 3696 WP_003898790.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
M7V54_RS06665 1393200..1393988 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T263990 WP_003898789.1 NZ_CP110619:c1388984-1388691 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT263990 WP_003406322.1 NZ_CP110619:c1389250-1388981 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References