Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1384284..1384972 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag M7V54_RS06630 Protein ID WP_003406304.1
Coordinates 1384541..1384972 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag M7V54_RS06625 Protein ID WP_003406302.1
Coordinates 1384284..1384544 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS06605 1379861..1380685 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
M7V54_RS06610 1380690..1381871 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
M7V54_RS06615 1381948..1383048 - 1101 WP_003916789.1 magnesium/cobalt transporter CorA -
M7V54_RS06620 1383219..1384208 + 990 WP_003406301.1 malate dehydrogenase -
M7V54_RS06625 1384284..1384544 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
M7V54_RS06630 1384541..1384972 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
M7V54_RS06635 1384995..1386683 - 1689 WP_003910308.1 PE family protein -
M7V54_RS06640 1386863..1387723 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
M7V54_RS06645 1387804..1388634 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
M7V54_RS06650 1388691..1388984 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
M7V54_RS06655 1388981..1389250 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T263989 WP_003406304.1 NZ_CP110619:1384541-1384972 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT263989 WP_003406302.1 NZ_CP110619:1384284-1384544 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References