Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1024215..1025188 | Replicon | chromosome |
| Accession | NZ_CP110619 | ||
| Organism | Mycobacterium tuberculosis strain H37Rv-1 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | O05911 |
| Locus tag | M7V54_RS04880 | Protein ID | WP_003404756.1 |
| Coordinates | 1024688..1025188 (+) | Length | 167 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | O05910 |
| Locus tag | M7V54_RS04875 | Protein ID | WP_003898647.1 |
| Coordinates | 1024215..1024691 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M7V54_RS04855 | 1020062..1021333 | - | 1272 | WP_003404747.1 | PPE family protein | - |
| M7V54_RS04860 | 1021348..1021647 | - | 300 | WP_003404748.1 | PE family protein | - |
| M7V54_RS04865 | 1022091..1023872 | + | 1782 | WP_003404749.1 | BCCT family transporter | - |
| M7V54_RS04870 | 1023872..1024126 | + | 255 | WP_003898646.1 | hypothetical protein | - |
| M7V54_RS04875 | 1024215..1024691 | + | 477 | WP_003898647.1 | DUF1778 domain-containing protein | Antitoxin |
| M7V54_RS04880 | 1024688..1025188 | + | 501 | WP_003404756.1 | GNAT family N-acetyltransferase | Toxin |
| M7V54_RS04890 | 1025501..1026820 | - | 1320 | WP_003404757.1 | IS256-like element IS1554 family transposase | - |
| M7V54_RS04895 | 1027108..1027689 | + | 582 | WP_003404760.1 | IS607-like element IS1535 family transposase | - |
| M7V54_RS04900 | 1027689..1029341 | + | 1653 | WP_003404761.1 | IS607 family element RNA-guided endonuclease TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1023869..1069780 | 45911 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18048.55 Da Isoelectric Point: 7.8659
>T263985 WP_003404756.1 NZ_CP110619:1024688-1025188 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
Download Length: 501 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 17387.98 Da Isoelectric Point: 11.2467
>AT263985 WP_003898647.1 NZ_CP110619:1024215-1024691 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BSZ2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A5U0V8 |