Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1014685..1015304 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag M7V54_RS04825 Protein ID WP_003404726.1
Coordinates 1014870..1015304 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag M7V54_RS04820 Protein ID WP_003898641.1
Coordinates 1014685..1014864 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS04805 1010158..1011738 + 1581 WP_003909313.1 serine hydrolase -
M7V54_RS04810 1011735..1014128 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
M7V54_RS04815 1014401..1014559 + 159 WP_003404720.1 hypothetical protein -
M7V54_RS04820 1014685..1014864 + 180 WP_003898641.1 antitoxin Antitoxin
M7V54_RS04825 1014870..1015304 + 435 WP_003404726.1 SRPBCC family protein Toxin
M7V54_RS04830 1015402..1016175 + 774 WP_003404735.1 VOC family protein -
M7V54_RS04835 1016240..1016689 + 450 WP_003404738.1 hypothetical protein -
M7V54_RS04840 1016824..1017054 - 231 WP_003898642.1 hypothetical protein -
M7V54_RS04845 1017221..1018729 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
M7V54_RS04850 1018731..1019969 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T263984 WP_003404726.1 NZ_CP110619:1014870-1015304 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT263984 WP_003898641.1 NZ_CP110619:1014685-1014864 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References