Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 703247..703890 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag M7V54_RS03205 Protein ID WP_003403187.1
Coordinates 703489..703890 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag M7V54_RS03200 Protein ID WP_003403184.1
Coordinates 703247..703492 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS03165 698527..699057 - 531 WP_003917320.1 two component system sensor kinase HK2 -
M7V54_RS03170 699041..699736 - 696 WP_003918099.1 two-component system response regulator TcrA -
M7V54_RS03175 699859..700170 + 312 WP_003403164.1 hypothetical protein -
M7V54_RS03180 700242..701192 + 951 WP_003900184.1 DUF1259 domain-containing protein -
M7V54_RS03185 701433..702017 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
M7V54_RS03190 702019..702729 + 711 Protein_632 IS607 family element RNA-guided endonuclease TnpB -
M7V54_RS03195 702732..703202 + 471 WP_003898523.1 hypothetical protein -
M7V54_RS03200 703247..703492 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M7V54_RS03205 703489..703890 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
M7V54_RS03210 703881..704060 + 180 Protein_636 hypothetical protein -
M7V54_RS03215 704478..704675 - 198 WP_003403191.1 hypothetical protein -
M7V54_RS03220 704755..705912 - 1158 WP_003898524.1 hypothetical protein -
M7V54_RS03225 705964..706185 - 222 WP_003898525.1 DUF4926 domain-containing protein -
M7V54_RS03230 706327..706932 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T263975 WP_003403187.1 NZ_CP110619:703489-703890 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT263975 WP_003403184.1 NZ_CP110619:703247-703492 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References