Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 640231..640907 Replicon chromosome
Accession NZ_CP110619
Organism Mycobacterium tuberculosis strain H37Rv-1

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag M7V54_RS02900 Protein ID WP_003898500.1
Coordinates 640231..640644 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag M7V54_RS02905 Protein ID WP_003402915.1
Coordinates 640641..640907 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7V54_RS02870 635576..635878 - 303 WP_003402896.1 DUF3349 domain-containing protein -
M7V54_RS02875 635938..636216 - 279 WP_003402901.1 hypothetical protein -
M7V54_RS02880 636213..637466 - 1254 WP_003911224.1 inorganic phosphate transporter -
M7V54_RS02885 637586..637972 - 387 WP_003402907.1 VOC family protein -
M7V54_RS02890 638035..638919 - 885 WP_003402909.1 SDR family oxidoreductase -
M7V54_RS02895 639015..639917 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
M7V54_RS02900 640231..640644 - 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
M7V54_RS02905 640641..640907 - 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
M7V54_RS02910 641099..642814 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
M7V54_RS02915 642892..644496 + 1605 WP_003402920.1 amidohydrolase -
M7V54_RS02920 644493..645473 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T263971 WP_003898500.1 NZ_CP110619:c640644-640231 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT263971 WP_003402915.1 NZ_CP110619:c640907-640641 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References